695 B AND T CELL ASSAYS IN ACUTE LYMPHOBLASTIC LEUKAEMIA
نویسندگان
چکیده
منابع مشابه
Clinical Relevance of Notch1 in T-Cell Acute Lymphoblastic Leukaemia
Notch1 signalling is an essential event in the thymopoiesis. Activating Notch1 mutations are frequently seen in T-Acute Lymphoblastic Leukaemia (T-ALL). Notch1 is mainly involved in the T cell proliferation, differentiation and apoptosis. The mutations in the Notch1 have been reported in more than 50% of T-ALL cases. The aberrant Notch1 signalling has a prominent role in the biology of T-ALL. A...
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Infant T-cell acute lymphoblastic leukaemia (iT-ALL) is a very rare and poorly defined entity with a poor prognosis. We assembled a unique series of 13 infants with T-ALL, which allowed us to identify genotypic abnormalities and to investigate prenatal origins. Matched samples (diagnosis/remission) were analysed by single nucleotide polymorphism-array to identify genomic losses and gains. In th...
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Considerable heterogeneity of lymphoblast morphology in childhood B cell acute lymphoblastic leukaemia has been observed. One case showed unusual monocytic features and emphasised the need for marker studies in the accurate definition of acute lymphoblastic leukaemia phenotypes. B cell acute lymphoblastic leukaemia is rare but may have been previously underestimated by morphological misinterpre...
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Soluble HLA (sHLA) are potential tumour markers released in order to counter immune surveillance. sHLA-class II is less known especially in acute lymphoblastic leukaemia (ALL). This study aimed to investigate soluble, surface and allelic expression of HLA Class II (sHLA-DR) in B-cell ALL patients and compare with soluble expression in normal individuals. A sandwich enzyme-linked immunosorbent a...
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Two cases of acute lymphoblastic leukaemia (A.L.L.) of T-cell type are reported. Clinically they were characterized by very high peripheral blood blast cell counts at presentation, the early development of meningeal leukaemia, and relative resistance to treatment with combination chemotherapy. Leukaemic cells from both patients lacked all the B-cell markers investigated, but 60-65% of their cel...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1978
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-197804001-00700